Traveling and Smoking during Pregnancy leads to Obesity

The next two weeks I'll be busy traveling for different meetings, so my posting will be extra light. However, before I embark on my travels, I want to leave you with this headline from Yahoo! news: Smoking Mothers Lead to Fat Children.

Apparently, Japanese researchers have found that children of women who smoked at any time during pregnancy are three times as likely to be obese. This does not bode well for my state - which has the 5th highest obesity rate in the nation, and where nearly 30% of women smoke during pregnancy. It seems beyond low birth weight and prematurity, later obsesity is yet another reason to quit smoking if you become pregnant. Not to mention, you will reduce your risk for heart disease, cancer, and stroke.

Quitting smoking is difficult, but help is available.

PMS: You are what you eat - or something like that

Periods are bad enough without adding premenstrual agonies to the front end. You know what I'm talking about - the bloating, breast tenderness, irritability, fatigue, acne, crying spells, anxiety, and food cravings (chocolate, salt, both - do I hear chocolate covered pretzels anyone?) that occur a week or so before your period arrives.

There has been a lot written in the popular media about easing PMS symptoms through changes in diet, such as consuming less caffeine and sodium and increasing vitamin B intake. But a study published in the Journal of Women's Health actually looked at what proportion of the participants' diets consisted of what kinds of foods (e.g., fats, carbs, fiber) and how these proportions related to their premenstrual symptoms. The study consisted of 3,302 ethnically diverse women who participated in SWAN (Study of Women's Health Across the Nation). They did find some relationships between what women ate and how they felt. But you may be surprised by the results (I sure was).

Fat intake was associated with fewer premenstrual cravings and less bloating (potato chips okay). Caffeine was associated with more anxiety and mood changes (pumpkin spice latte from Starbuck's not okay). Alcohol consumption was associated with less anxiety and mood changes (glass of red wine okay), but more headaches (or maybe not okay). Fiber was associated with more breast pain (bran muffin maybe not okay, I'm still not sure about this one - see below).

Perhaps more important than the dietary findings, they found certain subgroups of women experienced PMS differently. Perimenopausal women reported significantly more premenstrual symptoms than premenopausal women. Additionally, women with depression reported more PMS symptoms, especially anxiety and mood changes. Conversely, 0lder women reported less anxiety, mood changes, and back pain. Finally, overweight and obese women reported more cravings and bloating than normal weight women.

Is there a dietary moral here? The authors of the study say no. With the exception of caffeine, most of the dietary relationships were in the opposite direction - that is, fat and alcohol were actually associated with fewer symptoms, not more. Additionally, I would add there are other benefits of fiber intake that may outweigh the monthly nuisance of breast pain (although I'm not someone who experiences breast pain, so I might be convinced otherwise). They also didn't time their study to measure food intake and then track subsequent symptoms in the same 2-week period. Had they done this, they might have identified some different relationships between food and symptoms. Perhaps the more important part of this study is the identification of subgroups of women who are at higher risk for PMS symptoms, namely perimenopausal women, overweight women, and women with depression. If you are in one of these subgroups and you experience PMS, talk to your health care provider about ways to alleviate your symptoms.

Facebook breastfeeding debate driving you to drink? Not so fast...

If you've been keeping up with the discussions about Facebook letting pro-anorexia members freely mingle (despite research that says "pro-ana" websites are bad for women) while they ban breastfeeding moms for posting pictures of their children eating (despite research that shows breastfeeding is good for women AND their children), you'll know it's enough to drive anyone to drink.

Not so fast. While research does suggest women may receive some benefits from alcohol consumption, new research published yesterday in the online version of the International Journal of Cancer shows caution is in order.

Researchers followed over 41,000 postmenopausal women of diverse ethnic backgrounds, including African-American, Japanese-American, Latina, Native-Hawaiian and White women. They tracked the women for an average of 8 years and recorded their dietary intake (including alcohol consumption), lifestyle decisions, genetic risk factors, and health outcomes. The investigators found women who drank 2 or more alcoholic beverages of any kind (wine, liquor, or beer) daily had twice the risk of contracting endometrial cancer (cancer of the lining of the uterus) as women who did not drink. They did not find an increased risk for endometrial cancer among women who consumed less than 2 alcoholic drinks daily.

When they separated women according to their preferred/most often consumed beverage, there were differences in rates of endometrial cancer. Women who drank 2 or more servings of wine daily were 3 times as likely to develop endometrial cancer as non-drinkers. Women who drank just 1 or more servings of hard liquor were on average twice as likely to develop endometrial cancer as those who abstained. The investigators did not find any differences among women who preferred beer, mostly because few women identified beer as their primary drink of choice.

The investigators also studied alcohol consumption in relation to other risk factors for endometrial cancer, such as body mass index, history of pregnancy, use of hormone replacement therapy, and smoking. They found lean women (women with a BMI less than 25) who consumed at least two drinks daily had greater risk for endometrial cancer than overweight and obese women. Women who never gave birth also were at greater risk for endometrial cancer if they consumed 2 or more drinks daily. Smokers and women who used hormone replacement therapy did not show increased risk for endometrial cancer based on their alcohol consumption.

So while you may derive some health benefits from enjoying your favorite libation, there also are some risks if you get too carried away too often. In addition to "how many" drinks you have, be mindful of how much you pour into a glass. (Do you ever notice a bottle of wine lasts longer in a restaurant - when someone else is pouring - than it does at home?). Here's a guide to standard serving sizes (yes, that reads 5 ounces for a glass of wine). Bottom line: moderation is key.

Pump it up: Strength training key for premenopausal women

Few women need to be convinced that exercise is good for them. Yet many women find it very difficult to make exercise part of their lives. The reasons for not exercising abound. I'm too tired. I don't have time. It's too cold/hot/rainy outside. A gym membership is too expensive. I've tried exercise before, but I didn't lose weight. I can't get motivated. You get the picture.

New research, however, suggests that just two weekly, one-hour dates with weights can have important positive health benefits for overweight and obese premenopausal women.

Investigators randomly placed 164 women into one of two groups: (1) a treatment group, where women were taught a stretching and weight-lifting routine that included both machines and free weights; and (2) a non-treatment group, where women were mailed an informational brochure from the American Heart Association on the recommended 30-minutes daily of moderate exercise. Both groups were told not to change their eating habits, and they were followed for two years.

Although the women in the treatment group did not lose weight, they did experience changes in their body composition. The women had less total body fat, a lower overall percentage of body fat, and less abdominal/mid-section fat. Further, the women who did not lift weights actually showed increases in total body fat, in the ratio of body fat to lean body mass, and in abdominal fat. The increase in belly fat is particularly concerning, because it is associated with higher risk for cardiovascular disease and metabolic disorders, including the metabolic syndrome.

The investigators suggested that strength training can help to slow weight gain and the development of obesity in women, which is on the rise. If you currently exercise but do not strength train, you might think about adding weights to your weekly routine - especially if you are overweight. Here are some weight training tips from the Mayo Clinic, as well as a slide show of strengthening exercises for major muscle groups. And for those of you who do not exercise at all, check with your doctor. Once you get the okay, there are a number of reliable resources to get you moving. And as for those excuses...

Avandia - the next Vioxx?

In two studies published in JAMA today, it appears that a popular class of drug for diabetes, known as thiazolidinedione (popular brand names = Avandia [rosiglitazone] and Actos [pioglitazone]) is causing some heart problems. Avandia was found to increase risk for heart attack by 42% and double the risk of heart failure. Actos also was found to increase the risk of heart failure, although it reduced risk of heart attack, stroke and death.

Actos and Avandia are used most often in the treatment of type 2 diabetes. The drugs act on similar mechanisms to lower glucose (blood sugar) levels in the body. They can be prescribed alone, or in conjunction with other therapies, such as insulin.

This is not the first time research has suggested these drugs may cause serious cardiac events. This past May, the New England Journal of Medicine published two studies that also revealed Avandia caused some heart problems. In response, a federal advisory panel met to discuss the drug and voted to keep it on the market. The FDA also placed stricter warnings on both Avandia and Actos in June.

Does this sound familiar? Drs. Solomon and Winkelmayer seem to think so. They wrote a great piece on common threads between the Vioxx case and the current findings on Avandia. It seems the jury is still out, because at present GlaxoSmithKline is keeping Avandia on the market. However, if this does become another Vioxx, let's hope GSK doesn't wait too long to do the right thing.

Meantime, if you're taking Avandia or Actos, you may want to discuss this new research with your health care provider. You also want to remember that good nutrition, exercise, and maintaining a healthy weight are also important for managing your type 2 diabetes.

Metabolic Syndrome: you can decrease your risk

Most people have heard about common diseases like high blood pressure, diabetes, and arthritis. However, few people know about the metabolic syndrome, which is a disorder that affects an estimated 25% of Americans (and growing), and is associated with serious disease.

The metabolic syndrome is a group of conditions related to your metabolism that occur at the same time. These conditions include: (a) obesity, especially around your belly/mid-section; (b) high blood pressure; (c) abnormal cholesterol levels, including low levels of the "good cholesterol" (HDL) and high levels of triglycerides, or fat in your blood; and (d) insulin resistance, where the normal process your body uses to get sugar (glucose) into your cells does not work, resulting in increased levels of both insulin and glucose in your blood. Having any one of these conditions increases your likelihood of heart disease, heart attack, type 2 diabetes, and stroke. However, having them in combination can double and even triple your risk.

The good news is that lifestyle changes are key to preventing and treating the metabolic syndrome. In a study published in this month's International Journal of Obesity, researchers followed 224 people (80% of whom were women) for one year after assigning them to one of four groups: (1) use of an appetite suppressant alone, (2) a lifestyle modification program to lose weight, (3) the appetite suppressant plus the group lifestyle modification, and (4) the appetite suppressant plus brief meetings with their primary care physicians on weight loss, food diaries, healthy food choices, etc.

All weight loss treatments were successful in helping participants lose weight. Further, they found that weight loss decreased risk for metabolic syndrome: for every 2.2 pounds lost, there was an 8% reduction in the risk for the disorder. Additionally, participants who lost at least 5% of their starting body weight were 59.2% less likely to have the metabolic syndrome, and those who lost at least 10% of their starting body weight were 83.2% less likely to have the metabolic syndrome. Essentially, lose weight - even just a couple of pounds - and you can reduce your risk for the metabolic syndrome and related diseases.

Other ways to prevent and treat the metabolic syndrome? Stop smoking, exercise most days, and eat fiber-rich foods. Sounds like just healthy living to me. Couldn't we all use a little more of that?

Breastfeeding is better for babies AND moms - so why is it discouraged?

As if it weren't enough that Applebee's in Lexington pushed a mom out of their restaurant for breastfeeding her baby in a back corner booth. (So much for that Kentucky law that states breastfeeding in public is legal. Of course, why we need laws for this I'm unclear, but that's for another post).

Now the federal government has toned down its ads to promote breastfeeding. You read correctly, toned down its ads, even though media relations experts advised them against softening the ads, because they wouldn't increase breastfeeding. I mean, why would the federal government want to increase breastfeeding rates? Who cares about the study published this year by the Agency for Healthcare Research and Quality (yes, an agency of the federal government) that showed breastfeeding contributes to good infant AND maternal health? According to this AHRQ study, children who are breastfed get fewer ear and respiratory infections, GI illnesses, and skin rashes. They're also less likely to have asthma, obesity, type 1 and 2 diabetes, and childhood leukemia, and less likely to die from sudden infant death syndrome (SIDS).

As for moms - women who breastfed were less likely to have type 2 diabetes, breast cancer, and ovarian cancer. Conversely, women who stopped breastfeeding early (before 6 months) or never breastfed at all were more likely to have postpartum depression.

So why are we spending money on an ad campaign for breastfeeding that will essentially have no effect on a mother's decision to breastfeed? Talk to your neighborhood pharmaceutical company - apparently it was the infant formula/pharmaceutical lobby that got the Department of Health and Human Services to tone down its ads, because they need to keep those revenues up. And not just in infancy mind you. They want to make sure kids keep needing their prescriptions well into childhood to take care of the asthma, ear infections, and diabetes they develop.

Are we really making health policy based on an industry that does better when people are unhealthy? I say nurse-in at Applebee's today - big PHRMA tomorrow.

Eat Better, Breathe Easier

Most everyone knows that eating a diet high in fruits, vegetables, whole grains, and lean meats reduces the risk of a number of diseases, including cancer and obesity. A study published this month shows that a healthy diet also reduces the risk of chronic obstructive pulmonary disease, or COPD. COPD occurs when the tubes that carry air in and out of the lungs are partially blocked, making it difficult to breathe. This finding is especially significant for women, because the COPD death rate for women nearly tripled between 1980 and 2000.

Smoking and second-hand smoke exposure are the main culprits of COPD, but not all smokers contract COPD. Additionally, this new study shows that even exsmokers had a lower risk of contracting COPD if they primarily consumed healthy foods. Also interesting: lean women (those with a body mass index less than 21) who consumed a higher fat diet with more refined sugars were more likely to contract COPD whether or not they exercised regularly.

Often smoking and poor eating habits go hand-in-hand, so it's clear that women who smoke are at an even greater risk for developing COPD than previously thought. However, these new findings also suggest that even women who used to smoke can help reduce their future risk for COPD by improving their diets. There are a number of resources available to improve eating habits. Here's a sample. Also visit with your doctor, who may be able to tell you about local resources in your community.

As for smoking...let's all breathe easier.

Weight Matters in Pregnancy: Part III

Last week I wrote two posts about how excess weight during pregnancy may result in poor infant outcomes, including large for gestational age newborns and a variety of birth defects. A study published this week provides further evidence for watching weight before and during pregnancy - only this time the evidence focuses on moms.

After reviewing long-term medical data from over 37,000 women who had live births in Israel, the researchers found that women who were diagnosed with gestational diabetes (diabetes during pregnancy) had increased risk for later cancer of the pancreas. They did not find the same cancer risk for women who had insulin-dependent (type I) diabetes.

What does this have to do with obesity, you ask? One of the primary risk factors for gestational diabetes is a high body mass index (BMI). And research shows that more and more women are being diagnosed with gestational diabetes - which is not surprising given the growing problem of overweight and obesity in the United States. So, I’ve said it before and I’ll say it again: If your BMI is high and you’re thinking about pregnancy, you may want to talk to your doctor about how to lose weight first. It’s a decision that will improve not only your baby’s health, but your own.

Weight Matters in Pregnancy: Part II

If my previous post on weight matters in pregnancy didn't convince you that starting your pregnancy obese can be bad for your baby, findings from a study published this week just might.

Researchers reviewed the birth outcomes of more than 4,000 women in eight states over a five-year period. They found that mothers who were obese (defined as a body mass index of 30 or greater) prior to pregnancy were significantly more likely to have infants with birth defects, including spina bifida, heart deformities, malformed rectums, hypospadias (abnormal opening of the urethra in males), short or missing limbs, hernias in the diaphragm, and abdominal wall defects. These researchers made sure that this was an obesity issue by not including infants whose birth defects had a known or suspected genetic cause and adjusting their calculations for women who took folic acid, which has been shown to reduce some birth defects.

I may sound like a broken record here, but the evidence continues to mount regarding the need to address overweight and obesity, especially among women of childbearing age. Additionally, given that: (1) Kentucky's rate of neural tube defects (such as spina bifida) is 1.5 times the national average; (2) birth defects are the leading cause of infant mortality in Kentucky; and (3) we already know that we're the fifth heaviest state in the nation, we've got some work to do if we want to meet our goals for improved birth outcomes in the Commonwealth.

Weight Matters in Pregnancy

Ask the average woman how much weight she should gain during pregnancy, and she'll probably respond 25-35 pounds. This Institute of Medicine guideline has been the practice for nearly 20 years. However, this recommendation is for normal weight women (i.e., body mass index [BMI] 18.5-24.9). The IOM also recommends that overweight and obese women limit their gestational weight gain according to their prepregnancy BMI.

A recent study, however, shows that many overweight and obese women are not limiting their weight gain during pregnancy, and this can have serious consequences for both the mother and newborn. In their study of over 7,500 women, researchers found that 64.3% of overweight and 52.9% of obese women gained more weight during pregnancy than recommended by the IOM for their BMI. Further, overweight and obese women were more likely to deliver by C-section and give birth to infants who were large for gestational age, with associated complications including the infant’s anterior shoulder becoming stuck above the pubic bones during delivery, birth canal lacerations, and fetal hypoglycemia (low blood sugar). Overweight/obese women also were less likely to initiate or continue breastfeeding beyond 10 weeks.

So if you are planning to become pregnant in the next year, take a look at your BMI. If you're above 25, talk to your doctor about steps to lose weight. Further, once you become pregnant, keep an eye on your diet and the scale. Pregnant women need only an additional 300 calories per day. By watching your weight before and during pregnancy, you'll not only improve your own health, but you'll also improve the health of your baby.

Stop Smoking, Start Gaining?

Many women who smoke say they are afraid to stop smoking for fear of gaining weight. However, new research suggests that reductions in smoking rates had less than a 1% effect on increased rates of obesity nationwide. Further, a forthcoming study shows that among weight-concerned smokers trying to quit, nicotine has only a small and temporary effect on weight maintenance.

What does contribute to weight gain? A social network analysis of over 12,000 people between 1971 and 2003 showed that friends and family are key. Individuals were 57% more likely to become obese if a friend became obese, 40% more likely if a sibling became obese, and 37% more likely if a spouse became obese. Further, same sex friends and family members had more influence on weight gain than opposite sex friends and family members.

So if you're worried about how quitting smoking might affect your waistline, fret no more. And whether you smoke or not, do take a look around your inner circle. If you see women friends and family members packing on the pounds, you may want to suggest a walk as opposed to a meal when spending time together.

Overweight = Undereducated

A researcher at the University of Texas has discovered that obese girls in America are half as likely to attend college as non-obese girls. This finding is particularly disturbing when you live and work in a state with the fifth highest adult obesity rate in the nation (25.6%) and the third highest rate of overweight high school students (14.6%) that ranks 45th in the percent of adults over age 25 with a bachelor's degree or higher (21.3% compared to 27.2% nationwide). As a health researcher, a citizen of the Commonwealth, and a woman, I worry and wonder - what are we going to do to promote the health and well-being of Kentucky's young women?

Obviously, there isn't a simple solution to the problems of obesity or low educational attainment. However, it is becoming increasingly obvious that schools are one venue for addressing these two critical issues facing the Commonwealth - perhaps even in an integrated fashion. If you saw the movie Akeelah and the Bee, you'll recall her jump rope spelling practice. Innovation such as integrated curriculum is key when working to tackle important issues.

Some of Kentucky's state senators and representatives agree. In the most recent general session, these lawmakers proposed legislation that would bring back physical education into the school day for grades pre-K through 8, including making physical activity a component of the three R's, a la' Akeelah. That sounds a lot better to me than how I received my physical education - running through the hills behind my elementary school with my 40-something fifth grade teacher cattle-prodding me (and the two other students bringing up the rear) to hurry along. Although this bill never made it to the Governor's desk in 2007, the good news is that Kentucky's legislature meets annually. So I'm holding out hope for 2008, especially in light of this recent research. Kentucky's girls deserve better, and I'm confident we can provide it for them.